Periodontal Disease and Neuroinflammatory Disorders
We recently came across an article in the Journal of Neuroinflammation that caught our eye. Not just because we are all a bunch of dental nerds… but because it was new research showing that the the health of our gums may play a significant role in influencing our brain health. So, with this new information, we wanted to break down the findings into non-clinical terms so everyone could better understand what we consider to be very interesting and important findings.
Understanding Periodontal Disease: Before delving into the connection with neuroinflammatory disorders, it's essential to grasp the basics of periodontal disease. Periodontal disease, commonly known as gum disease, is an inflammatory condition affecting the tissues surrounding the teeth. It is primarily caused by the accumulation of plaque – a sticky film of bacteria – on the teeth and gums. If left untreated, periodontal disease can progress, leading to gum recession, tooth loss, and systemic health implications.
The Neuroinflammatory Connection: Recent studies have indicated a bidirectional relationship between periodontal disease and neuroinflammatory disorders. Neuroinflammation refers to inflammation in the central nervous system, involving immune cells and various mediators. The link between these two seemingly distinct conditions lies in the inflammatory response triggered by periodontal pathogens.
Inflammatory Mediators: Periodontal disease results in the release of inflammatory mediators, such as cytokines and prostaglandins, into the bloodstream. These molecules can travel to the brain, contributing to neuroinflammation. The chronic exposure to inflammatory signals may lead to alterations in brain function and the development or exacerbation of neuroinflammatory disorders.
Immune System Activation: The immune system, activated in response to periodontal pathogens, can inadvertently attack the central nervous system. This immune system cross-reactivity might play a role in the onset or progression of neuroinflammatory conditions, including neurodegenerative diseases like Alzheimer's and Parkinson's.
Systemic Inflammation: Periodontal disease is recognized as a potential source of chronic systemic inflammation. Elevated levels of systemic inflammation are linked to various health problems, including those affecting the brain. The systemic inflammatory response triggered by periodontal disease may contribute to the development of neuroinflammatory disorders.
The Impact on Brain Health: The implications of this connection between periodontal disease and neuroinflammatory disorders extend beyond the oral cavity. Studies have suggested that individuals with chronic periodontitis may be at an increased risk of cognitive decline and neurodegenerative diseases. Maintaining optimal oral health, therefore, may have broader implications for preserving cognitive function and preventing neurological disorders.
As research in the field continues to unfold, the link between periodontal disease and neuroinflammatory disorders presents a compelling avenue for further exploration. It underscores the importance of oral health not only for maintaining a healthy smile but also for preserving overall well-being, including cognitive function. Taking proactive steps in preventing and treating periodontal disease may contribute to a healthier mouth and, potentially, a healthier brain.
If you’d like to read the entire medical journal sharing these findings, you can find it HERE.
Additionally, we’re attaching a quick snipet from a Gary Brecka podcast where he discusses the findings.